Which organ system is most commonly affected by sepsis?

The cardiovascular system is most commonly affected by sepsis due to the systemic inflammatory response it triggers. When the body is confronted with an infection, sepsis can lead to the release of inflammatory mediators into the bloodstream. This response can cause widespread vasodilation, increased vascular permeability, and ultimately, decreased blood pressure, leading to septic shock. The heart may also be affected, as sepsis can lead to altered myocardial contractility and arrhythmias.

While all organ systems can be impacted by sepsis, the cardiovascular system's response is particularly critical. It plays a pivotal role in maintaining perfusion and oxygen delivery throughout the body. In severe cases, the alterations within the cardiovascular system can lead to multi-organ dysfunction, making it essential to monitor and support this system closely in septic patients to prevent mortality.